Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

Glycerol is a small and simple molecule produced in the breakdown of glucose, proteins, pyruvate, triacylglycerols and other glycerolipid, as well as release from dietary fats. An increasing number of observations show that glycerol is probably involved in a surprising variety of physiopathologic mechanisms. Glycerol has long been known to play fundamental roles in several vital physiological processes, in prokaryotes and eukaryotes, and is an important intermediate of energy metabolism. Despite some differences in the details of their operation, many of (...) these mechanisms have been preserved throughout evolution, demonstrating their fundamental importance. In particular, glycerol can control osmotic activity and crystal formation and then act as a cryoprotective agent. Furthermore, its properties make it useful in numerous industrial, therapeutic and diagnostic applications. Few studies have focussed directly on glycerol, however, and while its metabolism is increasingly well documented, much of the details remain unknown. Considering the importance of glycerol in multiple vital physiological processes, its study could help unlock important physiopathological mechanisms. BioEssays 23:534–542, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Individuals exposed to dieting-related environmental cues have been repeatedly shown to be better able to resist tempting food. This especially applies to restrained eaters who hold a chronic dieting goal. Thus far, mainly short-term effects of environmental dieting cues have been examined and the individuals were typically unaware of being influenced. Yet, it is unclear whether individuals can deliberately apply environmental dieting cues for themselves to facilitate the pursuit of the longer-term goal of losing weight. The present longitudinal study applied (...) a 2 × 2 between-subjects design for 6 months. Our results provide preliminary indications that cue, awareness, and restrained eating interact. The results suggest that high restrained eaters could deliberately apply environmental dieting cues for themselves to facilitate losing weight. However, further studies are needed to explore the effects of environmental dieting cues over a longer period of time. (shrink)

Various studies have shown a decrease in well-being and an increase in mental health problems during the COVID-19 pandemic; however, only a few studies have explored fear, depression, and well-being cross-culturally during this time. Accordingly, we present the results of a cross-cultural study that compares these mental health scores for German and South African students, compares the correlations among them, and identifies COVID-19 fear, well-being, and depression predictors. German and South African societies differ from each other socio-culturally, politically, and economically. (...) Their university systems also differ to a large extent. University students in both countries completed the Fear of COVID-19 Scale, the World Health Organization-Five Well-Being Index, and the Patient Health Questionnaire-9. Welch’s t-test, correlation, and multiple regression analyses were performed. German students were found to have statistically lower levels of COVID-19 fear and depression, but lower levels of general well-being than South African students. In both samples, fear of COVID-19 was negatively correlated with well-being and positively associated with female gender and depression. Additionally, female gender, depression, and lower well-being were identified as predictors of COVID-19 fear in both samples. The findings indicate that the fear of COVID-19 is associated with and varies according to gender, depression, and well-being across cultures, and that the difference in the intensity of fear between German and South African students may be partly explained by cultural and contextual differences. These findings can create a deeper understanding of the pandemic’s impact on student communities and may be used by mental health practitioners and researchers to develop and apply culture-specific interventions. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

This paper studies the doctrinal and historical relations between the augustinian theme of the inner word as it was understood in Thirteenth-century thought --especially by Thomas Aquinas -- and William of Ockham's idea of mental discourse. The differences are shown to be deeply significant and are replaced in the context of a crucial shift that occurred in the decades between Aquinas and Ockham: the shift from theology to logic as providing the main inputs and stimulations for the development, on (...) an aristotelian basis, of a radically new sort of philosophy of mind. (shrink)

Cet article se penche sur la doctrine de l’abstraction chez les néo-scolastiques et ses sources immédiates pour en évaluer la fidélité par rapport à ses sources ultimes , avec insistance - terminologique et conceptuelle - sur la distinction thomasienne entre abstraction et séparation , une distinction aussi présente dans des textes de maîtres ès arts de l’Université de Paris contemporains ou même antérieurs, une distinction capitale - est-il rappelé en conclusion - par laquelle l’Aquinate limite épistémologiquement la portée de la (...) théologie philosophique. On prépare ainsi l’étude du témoignage jusqu’ici inédit des Communia logice sur ce thème de l’abstraction et de la séparation. (shrink)

Claude Geffré is one of the most important theologians in the past decades for his work in hermeneutics and in theological methodology. In the present article, he proposes his own intellectual biography and looks back at the evolution of catholic theology over the last forty years. While remaining faithful to the theological posture of Thomas of Aquinas, Geffré seeks to define theology as a hermeneutical science. For him, the task of theology is the presentation of a critical correlation (...) between the human experience and the texts of the Christian tradition. (shrink)

The purpose of this article is first to enrich the exposition on the contribution of the magistri artium in Claude Panaccio’s Le Discours intérieur by an in-depth scrutiny of a quotation from the Latin al-Fārābī ending the presentation of logic in the Divisio scientiarum (ca. 1250) of the Parisian Arts Master Arnoul of Provence (Arnulfus Provincialis). Once accomplished this revision using the various Latin versions or adaptations of the Farabian Enumeration of the sciences (Iḥṣāʾ al-ʿulūm) by Gerard of Cremona (...) and Gundissalinus, it is clear that, despite a certain duality in its manuscript tradition, the relevant passage in Arnulfus Provincialis’s Divisio scientiarum does not merely distinguish inner logos and external logos, but also considers, like its source, a third logos, and that in a way susceptible to refine the characterization of al-Fārābī’s triadic logos as Le Discours intérieur reports this triade at the occasion of its judicious comparison with a parallel doctrine in John Damascene (Ekdosis akribès tès orthodoxou pisteôs alias De fide orthodoxa) interpreted differently by Thomas Aquinas following Albert the Great. (shrink)

Throughout his intellectual career, John Dewey was asking the question of relationships between knowledge of common sense and scientific knowledge. We propose to examine these relations in the light of a comparison with Thomas Reid, one of the founding authors of the modern philosophy of common sense. This comparison tries to set up what should be considered as a closer formulation of what knowledge consists in: a matter of attitudes, a set of dispositions. Such a convergent formulation equally means (...) not to bring into conflict or contradiction – in the style of a “dualism” – what are common sense and scientific knowledge. In so doing, it is thus necessary to reshape an operative distinction between those two kinds of “attitudes”; and this distinction is not ontological but decisively methodological, epistemological and, on a practical level, political. (shrink)

La première édition, accompagnée d’une traduction française annotée, du témoignage des Communia logice sur l’abstraction, en fait la double abstraction, et la séparation - un thème philosophique dans la mouvance de Métaphysique, E, 1 notoirement présent, on l’a vu, à la même époque chez Thomas d’Aquin - est ici précédée d’une étude d’histoire littéraire et doctrinale de cette compilation exégétique de questions sur la logique contenue dans un manuscrit ayant appartenu à Pierre de Limoges, maître à la Faculté des (...) arts de l’Université de Paris au plus tard en 1260-1261 et peut-être responsable de l’insertion inattendue ainsi que de la structuration par amalgame dudit témoignage, en forme de débat sur le sujet des sciences mathématiques, dans le commentaire sur le prédicament de la quantité dans les Catégories. (shrink)

This book presents three of Blondel's important turn of the century articles. These are The Idealist Illusion, The Elementary Principle of a Logic of the Moral Life and in two parts, The Starting Point of Philosophy. These essays uncover a certain pragmatism in Blondel's thought while Fiachra Long's introduction argues that Blondel veered away from idealism and towards a logic of the concrete life which allied him closely if unwittingly with the Scottish common sense school of Thomas Reid.

Reprint of the first edition. This incisive critique was written around 1807 by Tracy [1754-1836], a French philosopher and path-breaking psychologist who was a friend of Jefferson [1743-1826]. Jefferson saw the Commentary when it was still a manuscript and was so impressed that he took pains to have it printed. He even helped with the translation and corrected the page proofs. Although the translation was published anonymously, we can identify the author and translators through a letter by Jefferson dated January (...) 26, 1811. Elsewhere in this letter he commends it for correcting the Spirit of the Laws. While other studies had merely "nibbled only at its errors...This want is now supplied, and with a depth of thought, recision of idea, of language and of logic, which will force conviction into every mind. I declare to you, Sir, in the spirit of truth and sincerity, that I consider it the most precious gift the present age has received.": The Writings of Thomas Jefferson V:566-571. (shrink)

« Rythmes et Croyances au Moyen-Âge » Journée d'études organisée par Marie Formarier et Jean-Claude Schmitt 23 juin 2012 – Paris Présentation : Cette journée d'études a eu pour objectif de faire dialoguer les diverses disciplines concernées par le rapport entre rythmes et croyances au Moyen-Âge. Elle a accueilli des historiens, des anthropologues, des sociologues, des philologues et des linguistes. Présents dans la langue latine et les langues vernaculaires, dans la rhétorique du sermon, la prière et (...) - Histoire (...) – NOUVELLE JOURNÉE d'ÉTUDES. (shrink)

One of a handful of truly pioneering figures in visual semiotics, Jean-Marie Floch elaborated an approach that combined an analysis of the basic perceptual qualities and compositional strategies of the image, with a study of the cultural and historical significance of its representational dimension. A key collaborator of A. J. Greimas, Floch situated his project within the theoretical framework of Paris semiotics, which he helped to develop. He positioned his visual studies of familiar cultural objects in proximity to cultural anthropology (...) and the work of Claude Lévi-Strauss. His five published monographs explore abstract painting, art photography, Russian icons, magazine advertisements, and comic books. (shrink)

One of a handful of truly pioneering figures in visual semiotics, Jean-Marie Floch elaborated an approach that combined an analysis of the basic perceptual qualities and compositional strategies of the image, with a study of the cultural and historical significance of its representational dimension. A key collaborator of A. J. Greimas, Floch situated his project within the theoretical framework of Paris semiotics, which he helped to develop. He positioned his visual studies of familiar cultural objects in proximity to cultural anthropology (...) and the work of Claude Lévi-Strauss. His five published monographs explore abstract painting, art photography, Russian icons, magazine advertisements, and comic books. (shrink)

Gaston Fessard (1897-1978) fait partie des penseurs politiques qui se sont livrés à une actualisation de l'antique notion de bien commun. Cette actualisation, qui s'opère au croisement de la philosophie hégélienne et de la théologie chrétienne, confère à la notion de bien commun une fonction à la fois de compréhension historique et de discernement politique. Fessard montre par exemple en quoi la dialectique des catégories du bien commun explique la destinée des sociétés depuis la Révolution française jusqu'au conflit des idéologies (...) qui traversent le XXe siècle.0Il expose également la manière dont la dialectique de ses contenus fournit des critères pour juger du gouvernement de Vichy et fonder une résistance en conscience au pouvoir du maréchal Pétain. Cet ouvrage présente la pensée du bien commun de Fessard à travers ses sources (Thomas d'Aquin, Hegel et Marx) et concepts, son application durant la Seconde Guerre mondiale, les controverses dans lesquelles elle fut impliquée (avec Kojève et Mounier) ou par rapport auxquelles elle mérite d'être située (querelle du personnalisme).0Il propose aussi une actualisation critique de cette pensée politique, quant au rôle international de l'Eglise ou encore aux exigences de la démocratie. Car Fessard n'invite pas seulement à jeter un regard rétrospectif sur de "sombres temps", mais également à examiner notre propre actualité historique."--Page 4 of cover. (shrink)

A brief personal history is given about how information theory can be applied to binding sites of genetic control molecules on nucleic acids. The primary example used is ribosome binding sites in Escherichia coli. Once the sites are aligned, the information needed to describe the sites can be computed using Claude Shannon’s method. This is displayed by a computer graphic called a sequence logo. The logo represents an average binding site, and the mathematics easily allows one to determine the (...) components of this average. That is, given a set of binding sites, the information for individual binding sites can also be computed. One can go further and predict the information of sites that are not in the original data set. Information theory also allows one to model the flexibility of ribosome binding sites, and this led us to a simple model for ribosome translational initiation in which the molecular components fit together only when the ribosome is at a good ribosome binding site. Since information theory is general, the same mathematics applies to human splice junctions, where we can predict the effect of sequence changes that cause human genetic diseases and cancer. The second example given is the Pribnow “box,” which, when viewed by the information theory method, reveals a mechanism for initiation of both transcription and DNA replication. Replication, transcription, splicing, and translation into protein represent the central dogma, so these examples show how molecular information theory is contributing to our knowledge of basic biology. (shrink)

A brief personal history is given about how information theory can be applied to binding sites of genetic control molecules on nucleic acids. The primary example used is ribosome binding sites in Escherichia coli. Once the sites are aligned, the information needed to describe the sites can be computed using Claude Shannon’s method. This is displayed by a computer graphic called a sequence logo. The logo represents an average binding site, and the mathematics easily allows one to determine the (...) components of this average. That is, given a set of binding sites, the information for individual binding sites can also be computed. One can go further and predict the information of sites that are not in the original data set. Information theory also allows one to model the flexibility of ribosome binding sites, and this led us to a simple model for ribosome translational initiation in which the molecular components fit together only when the ribosome is at a good ribosome binding site. Since information theory is general, the same mathematics applies to human splice junctions, where we can predict the effect of sequence changes that cause human genetic diseases and cancer. The second example given is the Pribnow “box,” which, when viewed by the information theory method, reveals a mechanism for initiation of both transcription and DNA replication. Replication, transcription, splicing, and translation into protein represent the central dogma, so these examples show how molecular information theory is contributing to our knowledge of basic biology. (shrink)

All too often it is said that common-sense philosophers faIl to justify their appeal to common sense as a philosophical standard, and that they merely repeat one another in the glorification of philosophical trivialities. This book challenges these and ot.

Dismissing criticisms that Leonard Peikoff's book, The DIM Hypothesis, is unscientific, deterministic, or rationalistic, this essay focuses on problems with the logical framework of Peikoff's study of Western culture. In particular, Peikoff has conflated two different kinds of rationalists and empiricists and has completely overlooked combinations of the Platonist and so-called “Kantian” modes. As a result, his three pure integration “modes” actually produce not just two “mixtures” but a total of six. Furthermore, without absolving Kant of very serious philosophical errors, (...) the author marshals evidence that the real culprit responsible for the culturally disastrous “Disintegration” mode was one of Kant's predecessors. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.3 (2003) 420-421 [Access article in PDF] Philip de Bary. Thomas Reid and Scepticism: His Reliabilist Response. New York: Routledge, 2002. Pp. xv + 203. Cloth, $90.00.Readers of Thomas Reid's An Inquiry into the Human Mind and his two Essays have long been puzzled by the philosophical purchase of his appeal to the principles of common sense. Writing in 1765, an (...) anonymous correspondent in the Monthly Review complained that Reid's use of the term "common sense" lacked precision, while Joseph Priestley claimed in 1774 that in the Inquiry Reid referred to no fewer than thirteen principles of common sense. According to Priestley, this proliferation of what he called "independent, arbitrary, instinctive principles" demonstrated that Reid had failed to capture the simplicity inherent in human nature, and consequently that Reid's system had to be rejected for methodological as well as empirical reasons. Reid was then attacked by an unidentified English critic for having ostensibly plagiarized the writings of Claude Buffier, while Kant famously affirmed in the preface to the Prolegomena to Any Future Metaphysics that Reid had completely missed the point of Humean scepticism, and that his invocation of common sense was little more than philosophical obfuscation. Further debate followed the publication of Reid's Essays on the Intellectual Powers of Man in 1785, with reviewers in the English and Critical Review challenging his account of our power of judgement and of the first principles of human reasoning. Even Dugald Stewart believed that Reid's use of the term "common sense" was ambiguous, and opted to reformulate Reid's ideas in terms of what Stewart called the "fundamental laws of human belief." Both friend and foe alike, therefore, found Reid's notion of common sense problematic, and the critical discussion of this feature of his writings continued unabated throughout the nineteenth century.In Thomas Reid and Scepticism, Philip de Bary is largely silent about this earlier literature and engages with the body of commentary on Reid's common sense epistemology written in the latter half of the twentieth century by such philosophers as Roger Gallie, Louise Marcil-Lacoste, Keith Lehrer, and Daniel Schulthess. De Bary's starting point is of a piece with his approach to the history of philosophy, for in his introduction he tells us that he will keep "the main focus of the discussion on those aspects of Reid's philosophy for which some direct contemporary relevance can be claimed" (2). Consequently, his interpretation of Reid's writings is primarily orientated toward current epistemological debates and he more or less ignores the details of Reid's historical context and the long tradition of critical commentary sketched above. Indeed, de Bary is not overly concerned with niceties of history because he sets out to "do 'history of philosophy' as philosophy rather than as history" (2). While this review is not the place to discuss the coherence of the enterprise thus described in any depth, de Bary can be seen as constructing a false dichotomy between philosophical and historical analysis and as overlooking the point that the study of the history of philosophy requires a firm grasp of both historical context and the intellectual issues at hand. Moreover, it would seem that if we genuinely want to learn from history, then we need to understand the thoughts and actions of historical actors in their own [End Page 420] terms rather than simply project our own problems onto the past. This means that our readings of texts must be rooted in the knowledge of their contexts, otherwise we run the risk of anachronism or worse.Such general worries notwithstanding, Thomas Reid and Scepticism provides a useful introduction to some of the major themes in Reid's philosophical works. At his best, de Bary displays many of the same virtues as Reid as a thinker. He is by turns patient, clear, and insightful, and he has many interesting things to say, even if the historical ground of his interpretation of Reid is occasionally shaky. In the course of the book he... (shrink)